Adding Quality Adjusted Life-Years (QALY’s) by nutraceutical food supplementation
Comhaire F1*, Decleer W2 , Deslypere JP1
lConsultant specialist internal medicine, endocrinology and metabolic diseases. Fertility Clinic. Weststraat, 16. 9900 Aalter. Belgium.
2Gynaecologist, specialist reproductive medicine. Fertility Clinic. Weststraat, 16. 9900 Aalter. Belgium.
*Comhaire F, Consultant specialistinternal medicine, endocrinologyand metabolic diseases. Fertility Clinic. Weststraat, 16. 9900 Aalter. Belgium.
figure 1:Box and whisker plot showing the percentage of methylation of the second dinucleotide (CpG2) of the hTERT promotor region in follicular cells of women having been treated by ovarian hyperstimulation for In Vitro Fertilization (IVF). The horizontal broken line corresponds with the percentage above which the risk of cancer development in the offspring is increased. The group “QALY®” had taken the food supplement during the process of ovarian stimulation, the group “No QALY®” had taken vitamin B9 (F-folic acid) only (with permission from ).
There are good reasons to accept that altered DNA methylation is associated with aging  and can be counteracted.
Another aspect of the administration of the nutraceutical concerns combating "inflammaging" . Long-lasting low-grade inflammation not only results from altered lymphocyte activity, but also from the continuous production of oxygen radicals by cellular metabolism. Oxidative stress induces inflammation, which together with DNA methylation, causes age-related tissue damage and malfunction. Oxygen radicals convert guanosine into 8-hydroxy-2-deoxyguanosin (8OH-2-dG) that is a DNA mutation  associated with carcinogenesis . The concentration of oxidized DNA can dramatically be reduced by anti-oxidant intake, such as the combination of Astaxanthin and ubiquinol Q10. In addition, reactive oxygen radicals change the composition of the fatty acids composing of the cell membrane, in particular that of the long-chain poly-unsaturated eicosapentaenoid and docosahexaenoid acids. The fluidity of the cell membrane diminishes and the three-dimensional structure of the inlaying receptors is disrupted. This leads to e.g. insulin resistance, or osteoporosis by poor efficiency of circulating estrogens because of altered estrogen receptor sensitivity. Changes of the cell membrane phospholipid composition are also related to aging an senescence . The antioxidants in the nutraceutical QALY® prevent oxidative damage to the fatty acid composition of the cell membrane maintaining its fluidity and optimal functionality. During their entire life, even starting before birth, modern humans are exposed to man-made persistent chemicals in the environment. These are mostly fat-soluble and increasing amounts accumulate in fat cells and tissues. Aside from direct cellular toxicity reducing cell division and renewal, these chemical exert hormone disrupting effects  and may impair the immune system. Selenium is an essential constituent of the enzyme glutathione peroxidase that can bind toxic chemicals and make them water-soluble so that they can be eliminated via urine. In this way the immune system is safeguarded and can effectively exert its protective function. It can be concluded that combining various antioxidants, such as the non-toxic carotenoid Astaxanthin and the oxido-reductase Ubiquinol Q10, with the anti-inflammatory extract of Mediterranean pine bark and Selenomethionine synergistically inhibit several mechanisms involved with aging [10,11].
figure 2:A number of biological markers, including parameters of lung function, telomere length, blood lipid concentrations and biometric variables have been assessed in a large cohort of healthy young persons at the ages of 26, 32 and 38 years (on the horizontal axis). The graph shows the changes of these variables expressed as Z-score (on the vertical axis). The increase of the concentration of HgbA1c is the most
prominent biomarker associated with ageing (with permission, ).
In addition to the anti-oxidant and anti-inflammatory ingredients of the composed nutraceutical, the extract of bitter melon (Momordica charantia) should be given to patients with the metabolic syndrome . This extract acts through the same 5’-AMP-activated protein kinase pathway as the allopathic Metformin, but it is non-toxic and it does not persist as environmental pollutant with xeno-estrogenic effect in surface waters. Moreover, Metformin intake did not reduce mortality rates, nor cardio-vascular disease, nor cancer , while increasing the risk of lactic acidosis  and renal damage. Momordica extract reverses insulin resistance and lowers the concentration of glycated hemoglobin A1C. Its therapeutic effect can be enhanced by combining it with alpha-lipoic acid, that has significant anti-oxidant effects and reinforces the activation of 5′-AMP-activated protein kinase (AMPK). Alpha lipoic acid also inhibits Nuclear Factor kappa B, that activates the production of inflammatory cytokines. The combined intake of the nutraceutical with Momordica extract and alpha lipoid acid was indeed found to halt the evolution of the metabolic syndrome to pre-diabetes and, ultimately, diabetes. Its therapeutic effect persists during many years of intake, with stabilization, or even reversal, of clinical complications such as NAFLD and neurological impairment .
This is a sample text. You can click on it to edit it inline or open the element options to access additional options for this element.