Volume 2 - Issue 5

Authors : Fawwaz Freih Alshammarie*, Yasmeen Ali Muraizeq, Rahaf Turki Aldhaban, Asma Mohammed Almutairi, Monerah Thaar Alshammari
The safe use of drugs remains a critical issue for all health care professionals include physicians, pharmacists and nurses as well as public (1). Drug reaction is defined by World Health Organization (WHO) as a response to a drug which is harms and unintended, occurs at normal doses used in human for the prophylaxis, diagnosis or therapy of disease (2). Multi-type reactions can result, including Stevens-Johnson syndrome, toxic epidermal necrolysis, and eosinophilia associated with drug reactions, or acute generalized exanthemata's pustulosis (3).
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Authors : Shazim Harunani*
Surgical abdomino-pelvic emergencies are clinical conditions of sudden onset that may require urgent operative intervention. Abdomino-pelvic surgical emergencies represents more than half of all emergency surgical admissions(1). Non traumatic abdominal surgical emergencies represent bulk of these(2). It comprises of 54% of the admissions in Saudi Arabia(3) while in United kingdom it represents about 50 % (2). In Kenya, we still do not have data regarding abdomino-pelvic emergencies as a whole, however studies about abdominal emergencies seperatately have been published.
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Authors : Kamela Skrame, Edmond Zaimi, Ergys Ramosaço, Elizana Petrela
Osteoarthritis (OA) is a degenerative disease of the joint which is characterizes by fibrillation and erosion in cartilage, chondrocyte proliferation and osteophyte formation at the joint margins, and sclerosis of subchondral bone1. Osteoarthritis affects all joints, but the knee joint is most often affected. Using data from the National Health Interview Survey, in the US, it is estimated that approximately 14 million people have symptomatic knee osteoarthritis2.
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Authors : Dr Denis Yahiaoui, Dr Marc Basik, Dr François Panet, Dr Lawrence Panasci*
Patients with metastatic triple negative breast cancer have a short median survival (17 months) (1). In these patients, first line chemotherapy results in less than 5% complete remissions while second or third line chemotherapy almost never results in sustained complete remission. Two important classes of anticancer drugs utilized to treat metastatic breast cancer are: (a) vinca alkaloids such as vinorelbine and (b) taxanes such as paclitaxel (2).
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Authors : Dr Arifa Aziz, Dr Adeeba Zaki, Dr Kiran Afraz, Afsheen Feroz
Bevacizumab is an angiogenesis inhibitor that is approved for the treatment of patients with metastatic colorectal cancer, advanced non squamous non-small cell lung cancer, metastatic renal cell carcinoma, recurrent glio-blastoma, advanced cervical cancer, and platinumresistant ovarian cancer. It is also approved for treatment of metastatic breast cancer(1).. Bevacizumab is typically administered intravenously in the dose range of 5–15 mg/ kg every 2 or 3 weeks.
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Authors : Roy S. Horowitz, M.D. ; Rivka Drezner Pollak, M.D. ; Meir Liebergall, M.D. ; Omer Or, M.D.
Ribbing Disease is a rare yet probably under-reported etiology for severe pain of the long bones, especially of the tibiae. Only few reported cases were published without any clear guidelines for diagnosis and treatment. Patients often go unnoticed for years until diagnosis is made, assuming diagnosis is made at all. There are few treatment options which can alleviate the patient symptoms, albeit none directly address the disease's etiology.
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