Sustained hyperactivity and lower blood pressure are influenced by the ANXRR16 chromosomic region in rats
Natalli GRANZOTTO1,3; Jéssica Cordeiro Oliveira SQUARIZ2,3; Eduardo Kuser1,3; Ariela Maína BOEDER1,3; Julia Fernandez Puñal ARAÚJO2,3; Pamela Ramborger ANJOS1,3, Guilherme Pasetto FADANNI1,3; Áurea Elizabeth LINDER1; André RAMOS3; Geison Souza IZÍDIO1,2,3#
1Graduate Program of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, Brazil.
2Graduate Program of Developmental and Cellular Biology, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, Brazil
3Behavioral Genetics Laboratory, Federal University of Santa Catarina, Florianopolis, Brazil
*Izídio, G. S, *Graduate Program of Pharmacology, Center of Biological Sciences, Federal University of Santa
Catarina, Florianopolis, Brazil.
**Graduate Program of Developmental and Cellular Biology, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, Brazil
***Behavioral Genetics Laboratory, Federal University of Santa Catarina, Florianopolis, Brazil
Figure 1- SHR and SLA16 rat strains submitted to the Open-Field repeated test (4 weeks to 24 months). (A) total locomotion in meters from males (B) and from females. Results are expressed as mean ± standard error of the mean. *Strain effect p<0.05. a=higher values; b=lower values. ANOVA with repeated measures and Duncan’s post hoc.
Figure 2: Systolic Arterial Pressure of males and females from SHR and SLA16 rat strains. Results are expressed as mean ± standard error of the mean. **Strain effect p<0.01; @Sex effect p<0.05; Two-way ANOVA.
Figure 3: Males SHR and SLA16 rat strains submitted to open-field after methylphenidate treatment. 2.5 months old (A) central locomotion, (C) total locomotion, and (E) time in the center. 4 months after (B) central locomotion, (D) total locomotion, and (F) time in the center. Results are expressed as mean ± standard error of the mean. **Strain effect p<0.01, *p<0.05; #Repetition effect p<0.05; Two-way ANOVA.
Figure 4: Females SHR and SLA16 rat strains submitted to open-field after methylphenidate treatment. 2.5 months old (A) central locomotion, (C) total locomotion, and (E) time in the center. 4 months after (B) central locomotion, (D) total locomotion, and (F) time in the center. Results are expressed as mean ± standard error of the mean. **Strain effect p<0.01, *p<0.05; #Repetition effect p<0.05; Two-way ANOVA.
Figure 5: SHR and SLA16 rat strains submitted to object recognition after methylphenidate treatment. 2.5 months old (A) males and (B) females recognition index testing. 4 months after (C) males and (D) females recognition index testing. Results are expressed as mean ± standard error of the mean. ## significant values against the “0” p<0.01; Student t-test.
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