Eyelid Squamous Cell Carcinoma (ESCC) is a rare malignant tumour that develops from the squamous cells of the eyelid epidermis, accounting for approximately 5-10% of all eyelid malignancies (1). The typical presentations as painless growth characterized by firm nodules or lesions, gradually progressive most commonly affecting the lower eyelid and lateral canthus. Early detection and appropriate treatment, usually through surgical excision, generally leads to a good prognosis, though regular monitoring is essential due to the risk of recurrence (2) (3). A 55-year-old patients came to tertiary hospital with complaints of persistent non-healing ulcer with raised nodule on the eyelid that shows progressive growth, local loss of eyelashes (madarosis) and distortion of the eyelid margin that affected normal blinking. While the condition was usually painless, patients often seek medical attention when they notice visible changes in eyelid appearance or experience irritation, though it was initially mistake for a stye or chalazion, leading to delayed presentation. CT scan revealed ill defined exophytic soft tissue density mass lesion with irregular border and few air density foci noted in right preseptal region on right side measuring 6*4.8*3.5 cms. The lesion exceeding to infraorbital and pre maxillary region inferiorly, abutting anterior wall of maxillary sinus and right orbit anteromedially. The case of Locally Advanced Infiltrative Squamous Cell Carcinoma of the Preseptal, Infraorbital, and Premaxillary Regions with Possible Perineural and Soft Tissue Invasion.
